Cellular dormancy enables survival during prolonged nutrient limitation by reversibly suppressing protein synthesis^(1-4). How inactive eukaryotic ribosomes are reactivated when nutrients return remains unclear. Here, using high-resolution in situ cryo-electron tomography in Schizosaccharomyces pombe, we identify SNOR, an SBDS domain-containing ribosome-associated factor that binds at the peptidyl transferase centre and contacts the hypusinated loop of […]
Winter in temperate and high latitudes imposes severe challenges for animal survival, associated with low ambient temperature and limited food availability. In some mammalian species, these challenges are met by hibernation, a state characterized by marked reduction in core temperature and metabolic activity. Despite these extreme conditions, hibernating mammals preserve cardiac function and avoid life-threatening […]
Kaltschmidt and Wittmann made significant advances in protein separation techniques by pioneering the two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) method. However, it possessed two serious weaknesses. One was the extremely strong oxidizing power of the polyacrylamide gel, and the other was the excessively high pH of 4.5 of the second-dimensional gel. Consequently, it could not […]
The European adder (Vipera berus), classified as critically endangered in Germany, faces severe threats from habitat loss, particularly the decline of primary habitats such as peatlands. Peatland restoration is essential but may pose risks when hibernacula are not considered during rewetting, potentially leading to flooding, site loss, and population declines. Similar risks arise from construction […]