ZAKα is a MAP3K that interacts with ribosomes and autophosphorylates upon widespread ribosome collisions mediating the ribotoxic stress response pathway. While activation of ZAKα determines downstream cell fate outcomes such as cell cycle arrest and apoptosis, the exact nature of ribosome binding and the mechanism of activation have not been fully understood. Our recent cryo-EM […]
What explains the large variation in lifespan across species? I examine an information-turnover proposition-that ancestral environmental variability should shorten captive lifespan after controlling for body mass, temperature and extrinsic mortality (P1), with a possible lineage-fate interaction (P2)-against the classical extrinsic-mortality prediction that safer niches permit longer life. I state the decision rules in advance rather […]
Recent studies have questioned the benefit of myocardial viability identification and its clinical impact on revascularization decisions. We aimed to evaluate whether F-18 fluorodeoxyglucose (F-18 FDG)-positron emission tomography (PET) influences real-world revascularization decisions and whether PET-defined viability helps predict improvement in ejection fraction (LVEF). We conducted a retrospective chart review of Rubidium-82 (Rb-82)/F-18 FDG PET […]
CONCLUSION: In a selected cohort of patients presenting with fixed defects on standard rest/stress sestamibi SPECT MPI, supplementary imaging with thallium myocardial CZT SPECT provided incremental data, altering the clinical interpretation in nearly 80% of patients. However, in the absence of an independent viability reference standard, this finding represents intertracer diagnostic reclassification rather than proven […]
Hibernation is a unique survival strategy employed by certain mammals to endure cold, food-scarce winter conditions. During hibernation, animals reduce energy expenditure through physiological adjustments, including decreased body temperature, metabolic rate, heart rate, and respiratory frequency, thereby ensuring survival in hostile environments. Despite these profound physiological fluctuations, their cardiovascular system shows no apparent pathological damage. […]