Glaucoma is a group of eye diseases that affects 4 million people in the US and is one of the leading causes of vision loss due to damage to the eye's optic nerve (ON) which is composed of axons from retinal ganglion cells (RGCs) that transmit visual information to the brain. Injury to the ON […]
Homeothermy, the physiologic capacity to maintain a constant core body temperature, provided a critical survival advantage for mammalian and avian phyla, enabling the colonization of diverse habitats. However, the higher metabolic demands associated with homeothermy necessitate greater food intake. When challenged by food deprivation or harsh environmental conditions, many mammalian and avian species initiate adaptive […]
Stroke continues to be a leading cause of death and long-term neurological disability globally, with current treatment options limited by narrow time windows and insufficient neuroprotective strategies. Over recent decades, research into effective neuroprotective interventions has advanced significantly, shifting from single-target approaches like excitotoxicity modulation to recognizing the diverse protective potential of therapeutic hypothermia (TH). […]
At 6°C, when atria of most mammals cannot be activated, isolated atria of 13-lined ground squirrels, a model hibernator, have intracellular action potentials (AP) that are enlarged in duration and overshoot. Avoidance or delay of inactivation was postulated as playing a role in the retention and enhancement of the AP. In a published genomic study, […]
Bacterial biofilms contain physiologically diverse subpopulations of cells, including cells that are nutrient stressed or dormant. We determined how two dormancy pathways, ribosome hibernation and the stringent response, contribute to the survival and antibiotic tolerance of Pseudomonas aeruginosa biofilms. Analyses of whole biofilms and single cells showed that these pathways have differing effects on biofilm […]