Brain activity is costly, and aerobic metabolism supplies ∼90% of the ATP for cellular and synaptic function. Accordingly, oxygen consumption varies to match activity demands of neural circuits, and mitochondrial defects that reduce aerobic metabolism cause various neurological disorders. Brain activity in frogs has energy demands typical of an average vertebrate, but surprisingly, improves function […]
Cancer dormancy, a period of cellular hibernation, enables malignant cells to evade treatment and later initiate metastatic relapses, representing a central challenge in oncology. This review synthesizes the evidence that defines metabolic reprogramming as an essential hallmark of this persistent state. The authors find that dormant cells adopt a distinct bioenergetic identity, characterized by exceptional […]
Understanding thermoregulation within the range of low body temperatures (Tb) in homeotherms is of special interest in various life science fields. Here, we report that mice exhibit long-lasting hypothermia induced by the administration of an A(1) adenosine receptor (A(1)AR) agonist, N⁶-cyclohexyladenosine (CHA), in combination with pretreatment with bezafibrates (BZ), a peroxisome proliferator-activated receptor α (PPARα) […]
Recent evidence demonstrates that tau phosphorylation, traditionally viewed as a hallmark of neurodegeneration, also occurs in completely reversible physiological contexts such as mammalian hibernation and human neonatal development. These findings challenge the classical protein-centric "proteinopathy" model of Alzheimer's disease (AD) and other tauopathies. Instead, we propose that phosphorylated tau (p-tau) functions as an adaptive molecular […]
Gut microbiota generally undergoes dynamic remodeling in concert with multifaceted self-regulation of amphibian hosts during key life stages, such as metamorphosis and hibernation. However, the spatiotemporal dynamics of amphibian gut microbiomes across the lifecycle remain poorly understood. In this study, we applied 16S rRNA gene amplicon sequencing to characterize the gut microbiomes of cultivated Black-spotted […]